707 South Duke St. - Notice the slope coming up the hill from the low area/creek up to Morehead.
The houses on the east side of the 700 block of South Duke St. were more clearly a part of Morehead Hills rather than West End. The dividing line was never clearly delineated, but the low ground between the high point at Chapel Hill St. and the high point at Morehead Ave. (low ground through which runs a tributary of Third Fork Creek, now culverted under the Durham Freeway) was the grey-est of the the grey area. The 700 block was continguous with the 600 block on the east side, divided by Parker St. on the west, which 'T-ed' into Duke St. The 700 block's southern boundary was Morehead Ave.
707 South Duke was the home of the Twaddell family. William P. Twaddell was director of the music department at the city high school, but was giving lessons and evidently available for work of all kinds musical out of his home. The city directory for 1923 reads: "Studio (piano, voice, organ, and musical theory,) concert organist and consulting choral director, psychological measurements of musical ability - 707 South Duke"
Evidently after his death, his wife, Vera Carr Twaddell, transformed this into a full-fledged musical school, beginning in September 1934. By 1951 it "had an enrollment of 225 pupils. With an adequate and qualified faculty, they offer instruction from kindergarten through the sixth grade. Subjects include piano, organ, voice, and ballet."
I've spoken to several residents of Durham who grew up during this era and remember going to the house on South Duke St. for music lessons.
I don't know when the school closed, but there's no sign by the mid-1960s. In 1967, the house was torn down to make way for the Durham Freeway.